منابع مشابه
The Kynurenine Transaminase of Rat Kidney*
The conversion of kynurenine to kynurenic acid was observed in intact animals by Kotake (2) in 1931. This reaction was studied in vitro by Mason and Berg (3, 4), who observed that slices and homogenates of rat liver converted both tryptophan and kynurenine to kynurenic acid. Similar preparations from rat kidney did not convert tryptophan to kynurenine or kynurenic acid, but had a somewhat great...
متن کاملThe kynurenine transaminase of rat kidney.
The conversion of kynurenine to kynurenic acid was observed in intact animals by Kotake (2) in 1931. This reaction was studied in vitro by Mason and Berg (3, 4), who observed that slices and homogenates of rat liver converted both tryptophan and kynurenine to kynurenic acid. Similar preparations from rat kidney did not convert tryptophan to kynurenine or kynurenic acid, but had a somewhat great...
متن کاملKynurenine transaminase of rat kidney; a study of coenzyme dissociation.
Cell-free extracts of rat kidney catalyze the conversion of kynurenine to kynurenic acid by means of a transamination reaction (2). Such extracts lose kynurenine transaminase activity rapidly when added to phosphate buffer solutions with pH below 7 unless ol-ketoglutarate is added (2). Further studies in this laboratory have shown that this inactivation is completely reversed by the addition of...
متن کاملSubcellular distribution and properties of kynurenine transaminase in rat liver.
Kynurenine transaminase activity in rat liver was found in both the mitochondrial and supernatant fractions. The mitochondrial and supernatant fractions contained (a) kynurenine-pyruvate transaminase, which showed a preference for pyruvate as amino acceptor and a pH optimum between 8.0 and 8.5, and (b) kynurenine-alpha-oxoglutarate transaminase, with a preference for alpha-oxoglutarate and a pH...
متن کاملKynurenine aminotransferase 3/glutamine transaminase L/cysteine conjugate beta-lyase 2 is a major glutamine transaminase in the mouse kidney
BACKGROUND Kynurenine aminotransferase 3 (KAT3) catalyzes the transamination of Kynurenine to kynurenic acid, and is identical to cysteine conjugate beta-lyase 2 (CCBL2) and glutamine transaminase L (GTL). GTL was previously purified from the rat liver and considered as a liver type glutamine transaminase. However, because of the substrate overlap and high sequence similarity of KAT3 and KAT1, ...
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ژورنال
عنوان ژورنال: THE JOURNAL OF VITAMINOLOGY
سال: 1962
ISSN: 0022-5398
DOI: 10.5925/jnsv1954.8.292